Associate Professor Adam Zweifach
Education: Ph.D., Yale University; Postdoctoral training, Stanford
Research Interests: T lymphocyte function; signal transduction and killing by cytotoxic T cells.
Calcium influx and signaling in cytotoxic T-lymphocyte lytic granule exocytosis.
Pores-Fernando AT, Zweifach A.
Immunol Rev. 2009 Sep;231(1):160-73.
PMID: 19754896 [PubMed - in process]
No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis.
Pores-Fernando AT, Ranaghan MY, Zweifach A.
J Biol Chem. 2009 Sep 11;284(37):25107-15. Epub 2009 Jul 10.
PMID: 19592494 [PubMed - in process]
Zweifach, A. 2000. Target cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes. The Journal of Cell Biology 148: 603-614.
Lyubchenko, T.A., G.A. Wurth and A. Zweifach. 2001. Role of calcium influx in the exocytosis of cytotoxic T lymphocyte lytic granules during target cell killing. Immunity 15: 847-859.
Fierro, A.F., G.A. Wurth and A. Zweifach. 2004. Crosstalk with Ca2+ influx does not underlie the role of extracellular signal regulated kinases in cytotoxic T lymphocyte lytic granule exocytosis. J. Biol. Chem. 279:25646-25652.
Pores-Fernando A.T., R.A. Bauer, G.A. Wurth and A. Zweifach. Exocytic responses of single leukemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor. 2005. The Journal of Physiology 567: 891-903.