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Professor Carolyn M. Teschke
picture Professor Carolyn M. Teschke
University of Connecticut
Molecular & Cell Biology, BSP 206
91 North Eagleville Road, Unit 3125
Storrs, CT 06269-3125

Telephone: (860) 486-4282
Fax: (860) 486-4331
E-Mail: carolyn.teschke@uconn.edu

Education: Ph.D., Washington State University; Post-doctoral training, Massachusetts Institute of Technology

Research Interests:
-Biochemical, biophysical, and mutational analysis of virus assembly, especially of the thermodynamics of capsid assembly and maturation reactions.
-The role of the two SecA homologs in protein export in Mycobacterium tuberculosis.
-Protein folding in vivo and in vitro. Interaction of folding intermediates with molecular chaperones.

Selected Publications:
1. Hou, J.M., D’Lima, N.G., Rigel, R.W., Gibbons, H.S., Braunstein, M., Teschke, C.M. (2008) ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance to SecA2 function in macrophages. J. Bacteriol., 190, 4880-7.
2. Parent, K.N., Suhanovsky, M.M., Teschke, C.M. (2007) Polyhead formation in phage P22 pinpoints a region in coat protein required for conformational switching. Molecular Microbiol. 65,1300-10.
3. Parent, K.N., Teschke, C.M. (2007) GroEL/S substrate specificity based on substrate unfolding propensity. Cell Stress and Chaperones, 12, 20-32.
4. Parent, K.N., Suhanovsky, M.M., Teschke, C.M. (2007) Phage P22 procapsids equilibrate with free coat protein subunits. J. Mol. Biol., 365, 513-22.
5. Parent 4. K.N., Zlotnick, A., Teschke, C.M. (2006) Quantitative analysis of multi-component spherical virus assembly: Scaffolding protein contributes to the global stability of phage P22 procapsids. J. Mol. Biol., 359,1097-106.