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Associate Professor Andrew Pask
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Associate Professor Andrew Pask
University of Connecticut
Molecular and Cell Biology, BH 307
354 Mansfield Road - Unit 2131
Storrs, CT 06269-2131
Telephone: 486-1899
Fax: 486-1936
E-Mail: andrew.pask@uconn.edu
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Education: B.Sc LaTrobe University, Bundoora, Australia. Ph.D. LaTrobe University, Bundoora, Australia
Research Interests: Reproductive Development and Disease; My lab uses alternative model organisms to understand developmental processes associated with the reproductive system differentiation and disease. Comparative Vertebrate Genomics; We use comparative genomics to understand evolutionary processes at the molecular level.
Selected Publications:
Renfree MB, Papenfuss AT, Deakin JE, Lindsay J, Heider T, Belov K, Rens W, Waters PD, Pharo EA, Shaw G, Wong ES, Lefevre CM, Nicholas KR, Kuroki Y, Wakefield MJ, Zenger KR, Wang C, Ferguson-Smith M, Nicholas FW, Hickford D, Yu H, Short KR, Siddle HV, Frankenberg SR, Chew KY, Menzies BR, Stringer JM, Suzuki S, Hore TA, Delbridge ML, Mohammadi A, Schneider NY, Hu Y, O’Hara W, Al Nadaf S, Wu C, Feng ZP, Cocks BG, Wang J, Flicek P, Searle SM, Fairley S, Beal K, Herrero J, Carone DM, Suzuki Y, Sagano S, Toyoda A, Sakaki Y, Kondo S, Nishida Y, Tatsumoto S, Mandiou I, Hsu A, McColl KA, Landsell B, Weinstock G, Kuczek E, McGrath A, Wilson P, Men A, Hazar-Rethinam M, Hall A, Davies J, Wood D, Williams S, Sundaravadanam Y, Muzny DM, Jhangiani SN, Lewis LR, Morgan MB, Okwuonu GO, Ruiz SJ, Santibanez J, Nazareth L, Cree A, Fowler G, Kovar CL, Dinh HH, Joshi V, Jing C, Lara F, Thornton R, Chen L, Deng J, Liu Y, Shen JY, Song XZ, Edson J, Troon C, Thomas D, Stephens A, Yapa L, Levchenko T, Gibbs RA, Cooper DW, Speed TP, Fujiyama A, Graves JA, O’Neill RJ, Pask AJ, Forrest SM, Worley KC. Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biol. 2011 12(8):R81. [Epub ahead of print]
Tang P, Argentaro A, Pask AJ, ODonnell L, Marshall-Graves J, Familari M, Harley VR: Localization of the Chromatin Remodelling Protein, ATRX in the Adult Testis. J Reprod Dev 2011, 57:317-321.
Renfree MB, Pask AJ: Reproductive and Developmental Manipulation of the Marsupial, the Tammar Wallaby Macropus eugenii. Methods Mol Biol 2011, 770:457-473.
Huyhn K, Renfree MB, Graves JA, Pask AJ: ATRX has a critical and conserved role in mammalian sexual differentiation. BMC Dev Biol 2011, 11:39.
Hu Y, Yu H, Shaw G, Pask AJ, Renfree MB: Kallmann syndrome 1 gene is expressed in the marsupial gonad. Biol Reprod 2011, 84:595-603.
Hickford DE, Frankenberg S, Pask AJ, Shaw G, Renfree MB: DDX4 (VASA) Is Conserved in Germ Cell Development in Marsupials and Monotremes. Biol Reprod 2011.
Heider TN, Lindsay J, Wang C, ONeill RJ, Pask AJ: Enhancing genome assemblies by integrating non-sequence based data. BMC Proc 2011, 5 Suppl 2:S7.
Chung JW, Pask AJ, Yu H, Renfree MB: Fibroblast growth factor-9 in marsupial testicular development. Sex Dev 2011, 5:131-140.
Chung JW, Pask AJ, Renfree MB: Seminiferous cord formation is regulated by Hedgehog signalling in the marsupial. Reproductive Biology 2011.
Pask AJ, Calatayud NE, Shaw G, Wood WM, Renfree MB: Oestrogen blocks the nuclear entry of SOX9 in the developing gonad of a marsupial mammal. BMC Biol 2010, 8:113.
Frankenberg S, Pask A, Renfree MB: The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial. Dev Biol 2010, 337:162-170.
Calatayud NE, Pask AJ, Shaw G, Richings NM, Osborn S, Renfree MB: Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii. Reproduction 2010, 139:599-611.
Yu H, Pask AJ, Shaw G, Renfree MB: Comparative analysis of the mammalian WNT4 promoter. BMC Genomics 2009, 10:416.
Wilson JD, Renfree MB, Auchus RJ, Pask AJ, Shaw G: Formation of 5alpha-reduced androgens in the testes and urogenital tract of the grey short-tailed opossum, Monodelphis domestica. Reprod Fertil Dev 2009, 21:649-654.
Tsend-Ayush E, Lim SL, Pask AJ, Hamdan DD, Renfree MB, Grutzner F: Characterisation of ATRX, DMRT1, DMRT7 and WT1 in the platypus (Ornithorhynchus anatinus). Reprod Fertil Dev 2009, 21:985-991.
Renfree MB, Papenfuss AT, Shaw G, Pask AJ: Eggs, embryos and the evolution of imprinting: insights from the platypus genome. Reprod Fertil Dev 2009, 21:935-942.
Renfree MB, Hore TA, Shaw G, Graves JA, Pask AJ: Evolution of genomic imprinting: insights from marsupials and monotremes. Annu Rev Genomics Hum Genet 2009, 10:241-262.
Racine C, Pask AJ, Wijayanti GE, di Clemente N, Picard JY, Shaw G, Renfree MB, Josso N: Early expression of the androgen receptor in the sertoli cells of a marsupial coincides with downregulation of anti-Mullerian hormone at the time of urogenital virilization. Sex Dev 2009, 3:317-325.
Pask AJ, Papenfuss AT, Ager EI, McColl KA, Speed TP, Renfree MB: Analysis of the platypus genome suggests a transposon origin for mammalian imprinting. Genome Biol 2009, 10:R1.
Hu Y, Yu H, Pask AJ, OBrien DA, Shaw G, Renfree MB: A-kinase anchoring protein 4 has a conserved role in mammalian spermatogenesis. Reproduction 2009, 137:645-653.
Warren WC, Hillier LW, Marshall Graves JA, Birney E, Ponting CP, Grutzner F, Belov K, Miller W, Clarke L, Chinwalla AT, et al: Genome analysis of the platypus reveals unique signatures of evolution. Nature 2008, 453:175-183.
Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, et al: Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet 2008, 40:971-976.
Renfree MB, Ager EI, Shaw G, Pask AJ: Genomic imprinting in marsupial placentation. Reproduction 2008, 136:523-531.
Pask AJ, McInnes KJ, Webb DR, Short RV: Topical oestrogen keratinises the human foreskin and may help prevent HIV infection. PLoS One 2008, 3:e2308.
Pask AJ, Behringer RR, Renfree MB: Resurrection of DNA function in vivo from an extinct genome. PLoS One 2008, 3:e2240.
Menzies BR, Shaw G, Fletcher TP, Pask AJ, Renfree MB: Exon 3 of the growth hormone receptor (GH-R) is specific to eutherian mammals. Mol Cell Endocrinol 2008, 296:64-68.
Edwards CA, Mungall AJ, Matthews L, Ryder E, Gray DJ, Pask AJ, Shaw G, Graves JA, Rogers J, Dunham I, et al: The evolution of the DLK1-DIO3 imprinted domain in mammals. PLoS Biol 2008, 6:e135.
Deakin JE, Koina E, Waters PD, Doherty R, Patel VS, Delbridge ML, Dobson B, Fong J, Hu Y, van den Hurk C, et al: Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals. Chromosome Res 2008, 16:1159-1175.
Ager EI, Pask AJ, Shaw G, Renfree MB: Expression and protein localisation of IGF2 in the marsupial placenta. BMC Dev Biol 2008, 8:17.
Ager EI, Pask AJ, Gehring HM, Shaw G, Renfree MB: Evolution of the CDKN1C-KCNQ1 imprinted domain. BMC Evol Biol 2008, 8:163.
Wallis MC, Waters PD, Delbridge ML, Kirby PJ, Pask AJ, Grutzner F, Rens W, Ferguson-Smith MA, Graves JA: Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes. Chromosome Res 2007, 15:949-959
Wallis MC, Delbridge ML, Pask AJ, Alsop AE, Grutzner F, OBrien PC, Rens W, Ferguson-Smith MA, Graves JA: Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role. Cytogenet Genome Res 2007, 116:232-234.
Suzuki S, Ono R, Narita T, Pask AJ, Shaw G, Wang C, Kohda T, Alsop AE, Marshall Graves JA, Kohara Y, et al: Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting. PLoS Genet 2007, 3:e55.
Ager E, Suzuki S, Pask A, Shaw G, Ishino F, Renfree MB: Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Dev Biol 2007, 309:317-328.
Yu H, Pask AJ, Shaw G, Renfree MB: Differential expression of WNT4 in testicular and ovarian development in a marsupial. BMC Dev Biol 2006, 6:44.
Rapkins RW, Hore T, Smithwick M, Ager E, Pask AJ, Renfree MB, Kohn M, Hameister H, Nicholls RD, Deakin JE, Graves JA: Recent assembly of an imprinted domain from non imprinted components. PLoS Genet 2006, 2:e182.
Pask A, Wallis M, Ezaz T: Fourth international symposium on the biology of vertebrate sex determination. Bioessays 2006, 28:1144-1145.
Suzuki S, Renfree MB, Pask AJ, Shaw G, Kobayashi S, Kohda T, Kaneko-Ishino T, Ishino F: Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby. Mech Dev 2005, 122:213-222.
Renfree MB, Pask AJ, Shaw G: Sexual development of a model marsupial male. Australian Journal of Zoology 2005, 54:151-158.
Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR: A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol 2005, 19:972-981.
Park DJ, Pask AJ, Huynh K, Harley VR, Renfree MB, Graves JA: Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific function. Gene 2005, 362:29-36.
El-Mogharbel N, Deakin J, Tsend-Ayush E, Pask A, Graves JA: Assignment of the DMRT1 gene to tammar wallaby chromosome 3p by fluorescence in situ hybridization. Cytogenet Genome Res 2005, 108:362.
Pask AJ, Whitworth DJ, Mao CA, Wei KJ, Sankovic N, Graves JA, Shaw G, Renfree MB, Behringer RR: Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression. Biol Reprod 2004, 70:160-167.
Park DJ, Pask AJ, Huynh K, Renfree MB, Harley VR, Graves JA: Comparative analysis of ATRX, a chromatin remodeling protein. Gene 2004, 339:39-48.
Carvalho-Silva DR, ONeill RJ, Brown JD, Huynh K, Waters PD, Pask AJ, Delbridge ML, Graves JA: Molecular characterization and evolution of X and Y-borne ATRX homologues in American marsupials. Chromosome Res 2004, 12:795-804.
Pask AJ, Behringer RR, Renfree MB: Expression of DMRT1 in the mammalian ovary and testis--from marsupials to mice. Cytogenet Genome Res 2003, 101:229-236.
Park DJ, Pask AJ, Renfree MB, Graves JA: 3 RACE walking along a large cDNA employing tiered suppression PCR. Biotechniques 2003, 34:750-752, 754-756.
Pask AJ, Harry JL, Graves JA, ONeill RJ, Layfield SL, Shaw G, Renfree MB: SOX9 has both conserved and novel roles in marsupial sexual differentiation. Genesis 2002, 33:131-139.
Mattiske D, Pask AJ, Shaw JM, Shaw G: Structure and expression of the follicle-stimulating hormone receptor gene in a marsupial, Macropus eugenii. Mol Reprod Dev 2002, 63:24-31.
Whitworth DJ, Pask AJ, Shaw G, Marshall Graves JA, Behringer RR, Renfree MB: Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial. Gene 2001, 277:209-219.
Renfree MB, Pask AJ, Shaw G: Sex down under: the differentiation of sexual dimorphisms during marsupial development. Reprod Fertil Dev 2001, 13:679-690.
Pask A, Renfree MB: Sex determining genes and sexual differentiation in a marsupial. J Exp Zool 2001, 290:586-596.
Pask A, Graves JA: Sex chromosomes and sex-determining genes: insights from marsupials and monotremes. EXS 2001:71-95.
Pask AJ, Harry JL, Renfree MB, Marshall Graves JA: Absence of SOX3 in the developing marsupial gonad is not consistent with a conserved role in mammalian sex determination. Genesis 2000, 27:145-152.
Pask A, Renfree MB, Marshall Graves JA: The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination. Proc Natl Acad Sci U S A 2000, 97:13198-13202.
Pask A, Graves JA: Sex chromosomes and sex-determining genes: insights from marsupials and monotremes. Cell Mol Life Sci 1999, 55:864-875.
Pask A, Toder R, Wilcox SA, Camerino G, Graves JA: The candidate sex-reversing DAX1 gene is autosomal in marsupials: implications for the evolution of sex determination in mammals. Genomics 1997, 41:422-426.
Graves JA, Cook SI, Glas R, ONeill RJ, Pask AJ, Delbridge ML: Genes involved in male reproduction as targets for biocontrol of the brushtailed possum. . Journal of the Royal Society of New Zealand 1997, 45:62-72.
Book Chapters:
Pask A., and Graves JAM (2001) Sex chromosomes and sex determining genes: insights from marsupials and monotremes. In: Genes and Mechanisms in Vertebrate Sex Determination (EXS), Eds: Scherer, G & Schmid, M. Birkhauser Verlag, Basel, Switzerland. EXS. pp71-95.
Pask AJ & Renfree, MB (2010) Molecular Regulation of Marsupial Reproduction and Development. Ed J. Deakin, P Waters and JAM Graves Springer New York London Paris (In press November 2009)
Hore, TA, Renfree, MB, Pask, AJ and Graves, JAM (2010) Genomic imprinting 2009 In Marsupial Genetics and Genomics Ed J. Deakin, P Waters and JAM Graves Springer New York London Paris (In press November 2009)
Renfree MB and Pask, AJ (2010) Reproductive and developmental manipulation of the marsupial, the tammar wallaby Macropus eugenii. In Vertebrate Embryogenesis: Methods and Protocols Human Press, Springer Ed F Peligrini, Methods in Molecular Biology Series Editor J Walker ( in press, December 2009)
Pask AJ (2010) Genome of the platypus. McGraw-Hill year book in Science and Technology, McGraw-Hill (in press, June 2010).
Suzuki S, Ono R, Narita T, Pask AJ, Shaw G, Wang C, Kohda T, Alsop AE, Marshall Graves JA, Kohara Y, et al: Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting. PLoS Genet 2007, 3:e55.
Pask AJ, Paplinska JZ, Shaw G, Graves JA, Renfree MB: Marsupial WT1 has a novel isoform and is expressed in both somatic and germ cells in the developing ovary and testis. Sex Dev 2007, 1:169-180.
Ager E, Suzuki S, Pask A, Shaw G, Ishino F, Renfree MB: Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Dev Biol 2007, 309:317-328.
Yu H, Pask AJ, Shaw G, Renfree MB: Differential expression of WNT4 in testicular and ovarian development in a marsupial. BMC Dev Biol 2006, 6:44.
Rapkins RW, Hore T, Smithwick M, Ager E, Pask AJ, Renfree MB, Kohn M, Hameister H, Nicholls RD, Deakin JE, Graves JA: Recent assembly of an imprinted domain from non-imprinted components. PLoS Genet 2006, 2:e182.
Pask A, Wallis M, Ezaz T: Fourth international symposium on the biology of vertebrate sex determination. Bioessays 2006, 28:1144-1145.
Suzuki S, Renfree MB, Pask AJ, Shaw G, Kobayashi S, Kohda T, Kaneko-Ishino T, Ishino F: Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby. Mech Dev 2005, 122:213-222.
Renfree MB, Pask AJ, Shaw G: Sexual development of a model marsupial male. Australian Journal of Zoology 2005, 54:151-158.
Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR: A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol 2005, 19:972-981.
Pask AJ, Behringer RR, Renfree MB: Expression of DMRT1 in the mammalian ovary and testis--from marsupials to mice. Cytogenet Genome Res 2003, 101:229-236.
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University of Connecticut |