Board of Trustees Distinguished Professor Philip I. Marcus
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Board of Trustees Distinguished Professor Philip I. Marcus
University of Connecticut
Molecular & Cell Biology, TLS 281
91 North Eagleville Road, Unit 3125
Storrs, CT 06269-3125
Telephone: (860) 486-4254
Fax: (860) 486-5193
E-Mail: philip.marcus@uconn.edu
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Education: Ph.D. University of Colorado, Medical Center, 1957 (Microbiology/Biophysics)
Research Interests: Animal virology and the interferon system: development of the interferon system in the chicken embryo; interferon inducibility as a phylogenic marker of viruses for analysis of quasispecies populations; peroral use of cloned chicken interferon to control influenza viruses and as an immunoregulator; analysis of influenza virus populations for interferon inducing- and suppressing-particles, and for cell-killing (apoptosis-inducing) activity. Research conducted in a BSL-2+ virus laboratory.
Selected Publications:
Clonogenic Assay of Type A Influenza Viruses Reveals Noninfectious Cell-Killing (Apoptosis-Inducing) Particles. John M. Ngunjiri, Margaret J. Sekellick, and Philip I. Marcus. Journal of Virology 82(6), In press, 2008. http://jvi.asm.org/cgi/reprint/JVI.02221-07v1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=marcus%2C+p&author2=ngunjiri%2C+j&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Selected Publications: From 120. Super-sentinel chickens detect low-pathogenicity influenza virus. P.I. Marcus, T. Girshick, L. van der Heide, and M.J. Sekellick Emerging Infectious Diseases, In Press. Amelioration of influenza virus pathognesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene. A.N. Cauthen, D. E. Swayne, M.J. Sekelick, P.I. Marcus, and D.L. Suarez. Journal of Virology 81:1838-1847, 2007.
Celebrating the 50th anniversary of the discovery of interferon (Editorial). P.I. Marcus Journal of Interferon & Cytokine Research 27:87-89, 2007. Genesis of the "feeder cell": concept and practice. P.I. Marcus In Vitro Cellular and Developmental Bology (Animal) 42:235-237, 2006. Interferon induction by viruses. XXV. Adenoviruses as inducers of interferon in developmentally aged primary chicken embryo cells. P.I. Marcus and M.J. Sekellick Acta Microbiologica et Immunologica Hungarica 52:273-290, 2005. Interferon induction by viruses. XXIV. Interferon induction and/or production and its suppression by influenza A viruses. P.I. Marcus, J.M. Rojek, and M.J. Sekellick Journal of Virology 79:2880-2890, 2005. Chicken interferon type I inhibits infectious bronchitis virus replication and associated respiratory illness. J. Pei, M.J. Sekellick, P.I. Marcus, I.-S., and E. W. Collisson. Journal of Interferon & Cytokine Research 21(12):000-000, 2001 (In Press).
Immune status assessment by abundance of interferon-alpha and -gamma mRNA in chicken blood. R. Novak, K. Ester, V. Savic, M.J. Sekellick, P.I. Marcus, J.W. Lowenthal, O. Vainio, and W. L. Ragland. Journal of Interferon & Cytokine Research 21:643-651, 2001
Nomenclature of avian interferon proteins. J.W. Lowenthal, P.Staeheli, U. Schultz, M.J. Sekellick, and P.I. Marcus. Journal of Interferon & Cytokine Research 21:547-549, 2001.
Combined sequential treatment of interferon and dsRNA abrogates virus resistance to interferon action. P.I. Marcus and M.J. Sekellick. Journal of Interferon & Cytokine Research 21:423-429, 2001
Cellular responses in chickens treated with IFN-alpha orally, or inoculated with recombinant Marek's disease virus expressing IFN-alpha. K.W. Jarosinski, W. Jia, M.J. Sekellick, P.I. Marcus, and K.A. Schat. Journal of Interferon & Cytokine Research 21:287-296, 2001
Transient resistance of influenza virus to interferon action attributed to random multiple packaging and activity of NS genes. M.J. Sekellick, S. Carra, A. Bowman, D.A. Hopkins, and P.I. Marcus. Journal of Interferon & Cytokine Research 20:963-970, 2000
Chicken interferon action on avian viruses. I. Oral administration of chicken interferon-alpha ameliorates Newcastle disease. P.I. Marcus, L. van der Heide, and M.J. Sekellick. Journal of Interferon & Cytokine Research 19:881-885, 1999
The interferon system: Basic biology and antiviral activity. P.I. Marcus In "Encyclopedia of Virology," 2nd ed., Eds. R.G.Webster & A. Granoff, Academic Press, Volume 2:854-862, 1999
Chicken interferons type I and II enhance synergistically the antiviral state and nitric oxide secretion. M.J. Sekellick, J.W. Lowenthal, T.E. O'Neil, and P.I. Marcus. Journal of Interferon & Cytokine Research 18:407-414, 1998
Interferon induction by viruses: XXIII. Interferon induction as a quasispecies marker of vesicular stomatitis virus populations, P.I. Marcus, L.L. Rodriguez, and M.J. Sekellick. Journal of Virology 72:542-549, 1998. Chicken interferon gene: cloning, expression, and analysis. M.J. Sekellick, A.F. Ferrandino, D.A. Hopkins, and P.I. Marcus Journal of Interferon Research 14:71-79, 1994
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