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Professor Michael A. Lynes
picture Professor Michael A. Lynes
University of Connecticut
Molecular and Cell Biology, BSP 308
91 North Eagleville Road, Unit 3125
Storrs, CT 06269-3125

Telephone: (860) 486-4350
Fax: (860) 486-4331
E-Mail: michael.lynes@uconn.edu
Visit Professor Lynes's Website.

Education: Ph.D. University of North Carolina

Research Interests: Genetic and biochemical regulation of lymphocyte activation and differentiation in normal and stressed immune responses. Role of environmental toxicants in diseases of the immune system, and metallothionein-mediated mechanisms of immunotoxicity. Mechanisms of chemotactic cell movement.  Multiplexed microarray platforms for cell and protein detection.

Selected Publications:
R.T. Emeny, G. Marusov, D.A. Lawrence, J. Pederson-Lane, X. Yin, M.A. Lynes, Manipulations of metallothionein gene dose accelerate
the response to Listeria monocytogenes, Chemico-Biological Interactions (2009), doi:10.1016/j.cbi.2009.06.018

Lynes, M.A. and Yin, X. (2006) Metallothionein and anti-metallothionein, complementary elements of cadmium-induced renal disease. Tox Sci. 91: 1 - 3

Lynes, M.A., Zaffuto, K., Unfricht, D.W., Marusov, G., Samson, J.S., and Yin, X (2006) The physiological roles of extracellular metallothionein. Journal of Experimental Biology and Medicine. (in press).

Jin,G-B, Unfricht, D.W., Fernandez, S.M., and Lynes, M.A. (2006) Cytometer on a chip: Cellular phenotypic and functional analysis using grating-coupled surface plasmon resonance. Biosensors and Bioelectronics, 22: 200-206

Yin, X., Knecht,, D.A., and Lynes, M.A. (2005) A Stress Response Protein as Immunomodulator: Metallothionein has chemotactic activity BMC Immunology 6:21.

Lynes, M.A., Fontenot, A.P., Lawrence, D.A., Rosenspire, A,J., and Pollard, K.M.. (2006) Gene Effects on metal-mediated immunomodulation" Toxicology and Applied Pharmacology 210:9-16.

Unfricht,D.W., Colpitts, S.L, Fernandez,S.M., and Lynes, M.A. (2005) Grating-coupled surface plasmon resonance: a cell and protein microarray  platform, Proteomics,  5 (17) 4432 - 4442

Lynes, M.A. (2004) Solid Phase Immunoassays.  In Current Protocols in Toxicology. Maines, M.D., Costa, L.G., Hodgson, E.,  Lawerence, D.A., Oxolins ,T.R., and Reed, D.J.(eds.) John Wiley & Sons, Inc.

B.L. Lyons, M.A. Lynes, N. Hadjout, M. J. Joliat, D. A. Lawrence, M. Barber and L.D. Shultz "The Origins of Anemia in Autoimmune Viable Motheaten Mice" (2003) Exp. Hematol.31: 234-243.

Zieziulewicz, T.J., D. W. Unfricht, N. Hadjout, M. A. Lynes, and D.A. Lawrence 2003 "Shrinking the biologic world: nanobiotechnologies for toxicology" Tox. Sci. 2003 74: 235-244.