University of Connecticut |
Education: Ph.D. The University of Connecticut; Postdoctoral study, University of Alberta, Canada; Université de Liêge, Belgium; Visiting Senior Fellow, University of Oxford; Visiting Professor, University of Copenhagen. Research Interests: Protein structure and function using techniques of X-ray diffraction, kinetic methods and interactive computer graphics. Drug inhibition of enzyme catalysis; protein-protein interactions; investigation of enzyme mechanisms at the atomic level; high-speed, three-dimensional graphics modelling of biological marcomolecules. Selected Publications:
Alexandre P. Kuzin, Hansong Liu, Judith A. Kelly, and James R. Knox. 1995. Binding of cephalothin and cefotaxime to D-ala-D-ala peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended spectrum beta-lactamases. Biochemistry 34: 9532-9540. Judith A. Kelly, and Alexandre P. Kuzin. 1995. The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 Angstroms resolution. J. Mol. Biol., 254: 223-236. Judith A. Kelly, Alexandre P. Kuzin, Paulette Charlier, Emiline Fonze. 1998. X-ray Studies of Enzymes that Interact with Penicillins. Cellular and Molecular Life Sciences 54: 353-358. Michael A. McDonough, Herbert. E. Klei, and Judith A. Kelly. 1999. Crystal Structure of Penicillin G Acylase from the Bro1 Mutant Strain of Providencia rettgeri. Protein Science 8(10):1971-81. Wenlin Lee, Michael A. McDonough, Lakshmi P. Kotra, Zhi-Hong Li, Nicholas R. Silvaggi, Yoshifumi Takeda, Judith A. Kelly and Shahriar Mobashery. 2001. A 1.2Å Snapshot of a DD-Peptidase Catalyzing the Final Step of Bacterial Cell Wall Biosynthesis. Proceedings of the National Academy of Science, USA 98:1427-31. Silvaggi, N. R., K. Kaur, S. A. Adediran, R.F. Pratt, J. A. Kelly. 2004. Toward Better Antibiotics: Crystallographic Studies of a Novel Class of DD-Peptidase/ b -Lactamase Inhibitors. Biochemistry 43 (22):7046-7053. Silvaggi, N. R., H. R. Josephine, A. P. Kuzin, R. Nagarajan, R.F. Pratt, J. A. Kelly. 2005. Crystal Structures of Complexes Between the R61 DD-Peptidase and Peptidoglycan-mimetic b -Lactams: A Non-covalent Complex with a “Perfect Penicillin”. Journal of Molecular Biology 345 (3):521-533. linás A., N. Ahmed, M. Cordaro, A. P. Laws, J. M. Frère, M. Galleni, N. R. Silvaggi, J. A. Kelly, M. I. Page. 2005. The Inactivation of Baterial DD-Peptidase by b -Sultams. Biochemistry 44 (21):7738-7746. |
